Shortly before midnight on Thursday, January 21, 1892, a fire alarm was sounded from Box 92 in the heart of Indianapolis’ wholesale district. A few minutes later, Box 52 at Illinois and Georgia Streets was pulled. A fireman who was working that evening later told the Indianapolis News that the fire department instantly suspected serious trouble.   Box 52 was in front of the National Surgical Institute, a crowded orthopedic hospital located in old four-story hotel  “which has been looked upon for years as a dangerous place.”